top of page

Publications

2022

Non-Enzymatic Catalytic Asymmetric Cyanation of Acylsilanes
Nagano, T.; Matsumoto, A.; Yoshizaki, R.; Asano, K.; Matsubara, S.
Commun. Chem. 2022, 5, 45.

Commun. Chem. 2022_Nagano.png

データ駆動で有機分子をつくれるか?
Matsubara, S.
Chemistry Today 2022, 612.

2021

Catalytic Asymmetric Cycloetherification via Intramolecular Oxy-Michael Addition of Enols
Murata, R.; Asano, K.; Matsubara, S.
Tetrahedron 2021, 97, 132381.

Tetrahedron 2021_Murata.png

Unmasking Inherent Chirality within the Cubane Skeleton
Yoshino, N.; Kato, Y.; Shimada, Y.; Williams, C. M.; Matsubara, S.
Isr. J. Chem. 2021, 61, 380386.

Isr. J. Chem. 2021_Yoshino.jpg

Digitization of Organic Synthesis ---- How Synthetic Organic Chemists Use AI Technology ----

Matsubara, S.

Chem. Lett. 2021, 50, 475481.

Selected as the inside cover.

Chem. Lett. 2021_Matsubara.gif
Chem. Lett. 2021_Matsubara_Backcover.jpg

Multipoint Recognition of Molecular Conformations with Organocatalysts for Asymmetric Synthetic Reactions

Asano, K.

Bull. Chem. Soc. Jpn. 2021, 94, 694712.

Selected as the inside cover.

Bull. Chem. Soc. Jpn. 2020_Asano.png
Bull. Chem. Soc. Jpn. 2021_Asano_Inside

Preparation of 2-Aryl-3-silyl- and 2-Aryl-3-germyl-1,3-butadienes via Arylnickelation and Zinciomethylation
Yoshino, N.; Sharewa, B.; Ikeda, Z.; Matsubara, S.
Heterocycles 2021, 103, 769777.

Heterocycles 2020_Yoshino.png

2020

有機合成のデジタル化

Matsubara, S.

日本化学会情報化学部会誌 2020, 38, 8–11.

Desymmetrization of gem-Diols via Water-Assisted Organocatalytic Enantio- and Diastereoselective Cycloetherification

Murata, R.; Matsumoto, A.; Asano, K.; Matsubara, S.

Chem. Commun. 2020, 56, 12335–12338.

Selected as the inside back cover.

Highlighted in Synfacts 2020, 16, 1276.

Chem. Commun. 2020_Murata.png
Chem. Commun. 2020_Murata_inside back co

trans‐Cyclooctenes as Chiral Ligands in Rhodium-Catalyzed Asymmetric 1,4-Additions

Nagano, T.; Einaru, S.; Shitamichi, K.; Asano, K.; Matsubara, S.

Eur. J. Org. Chem. 2020, 71317133.

Selected as the Very Important Paper (VIP).

Selected as the Front Cover.

Highlighted in ChemistryViews.

Eur. J. Org. Chem. 2020_Nagano.png
Eur. J. Org. Chem. 2020_Nagano_Front Cov

Enantio- and Diastereoselective Construction of Contiguous Tetrasubstituted Chiral Carbons in Organocatalytic Oxadecalin Synthesis

Wada, Y.; Murata, R.; Fujii, Y.; Asano, K.; Matsubara, S.

Org. Lett. 2020, 22, 4710–4715.

Highlighted in Organic Chemistry Highlights in Organic Chemistry Portal.

Org. Lett. 2020_Wada.png

Cubane Chirality via Substitution of a “Hidden” Regular Tetrahedron

Yoshino, N.; Kato, Y.; Mabit, T.; Nagata, Y.; Williams, C. M.; Harada, M.; Muranaka, A.;

Uchiyama, M.; Matsubara, S.

Org. Lett. 2020, 22, 4083–4087.

Org. Lett. 2020_Yoshino.jpg

Nickel-Catalyzed Intermolecular Carbobromination of Alkynes

Takahashi, T.; Kurahashi, T.; Matsubara, S.

ACS Catal. 2020, 10, 3773–3777.

ACS Catal. 2020_Takahashi.gif

2019

Enantioselective Bromination of Axially Chiral Cyanoarenes in the Presence of Bifunctional Organocatalysts

Wada, Y.; Matsumoto, A.; Asano, K.; Matsubara, S.

RSC Adv. 2019, 9, 31654–31658.

RSC Adv. 2019, 9, 31654.png

Nickel-Catalyzed [5+2] Cycloaddition of 10π-Electron Aromatic Benzothiophenes with Alkynes To Form Thermally Metastable 12π-Electron Nonaromatic Benzothiepines

Inami, T.; Takahashi, T.; Kurahashi, T.; Matsubara, S.

J. Am. Chem. Soc. 2019, 141, 12541–12544.

J. Am. Chem. Soc. 2019, ASAP (Inami).gif

Chlorotrifluoromethylation of Terminal Olefins by Atom Transfer‐Type Radical Reaction Catalyzed by Cobalt Complexes

Maeda, K.; Kurahashi, T.; Matsubara, S.

Eur. J. Org. Chem. 2019, 4613–4616.

Eur. J. Org. Chem. 2019, 4613.jpg

Asymmetric Aza‐Diels–Alder Reaction with Ion‐Paired – Iron Lewis Acid – Brønsted Acid Catalyst

Tomifuji, R.; Kurahashi, T.; Matsubara, S.

Chem.—Eur. J. 2019, 25, 8987–8991.

Selected as the top 10% most downloaded paper.

Chem. Eur. J. 2019, Accepted Article (To

Cationic Cobalt Porphyrin-Catalyzed Allylation of Aldehydes with Allyltrimethylsilanes

Tomifuji, R.; Masuda, S.; Kurahashi, T.; Matsubara, S.

Org. Lett. 2019, 21, 38343837.

Org. Lett. 2019, ASAP (Tomifuji).gif

Asymmetric syn-1,3-Dioxane Construction via Kinetic Resolution of Secondary Alcohols Using Chiral Phosphoric Acid Catalysts

Matsumoto, A.; Asano, K.; Matsubara, S.

Asian J. Org. Chem. 2019, 8, 814–818.

Asian J. Org. Chem. 2019, Accepted Artic

Diastereoselective Synthesis of 1,3-Oxazolidines via Cationic Iron Porphyrin-catalyzed Cycloaddition of Aziridines with Aldehydes

Teranishi, S.; Maeda, K.; Kurahashi, T.; Matsubara, S.

Org. Lett. 2019, 21, 2593–2596.

Org. Lett. 2019, ASAP (Teranishi).gif

Organocatalytic Enantio- and Diastereoselective Construction of syn-1,3-Diol Motifs via Dynamic Kinetic Resolution of In Situ Generated Chiral Cyanohydrins

Matsumoto, A.; Asano, K.; Matsubara, S.

Org. Lett. 2019, 21, 2688–2692.

Org. Lett. 2019, ASAP (Matsumoto).png

Asymmetric Cycloetherification of in Situ Generated Cyanohydrins through the Concomitant Construction of Three Chiral Carbon Centers

Kurimoto, Y.; Nasu, T.; Fujii, Y.; Asano, K.; Matsubara, S.

Org. Lett. 2019, 21, 2156–2160.

Org. Lett. 2019, ASAP (Kurimoto).png

反応集積化と中分子合成――新しい合成手法の開発
Matsubara, S.
Chemistry & Chemical Industry 2019, 72, 121–123.

A Protocol for an Iodine–Metal Exchange Reaction on Cubane Using Lithium Organozincates

Kato, Y.; Williams, C. M.; Uchiyama, M.; Matsubara, S.

Org. Lett. 2019, 21, 473–475.

Org. Lett. 2019, ASAP (Kato).gif

Kinetic Resolution of Acylsilane Cyanohydrins via Organocatalytic Cycloetherification

Matsumoto, A.; Asano, K.; Matsubara, S.

Chem.—Asian J. 2019, 14, 116–120.

Selected as the Cover Feature.

Selected as the top 10% most downloaded paper.

Chem. Asian J. 2018, Accepted Article (M
Chem. Asian J. 2019, (Matsumoto)_Cover P

2018

H/D Exchange Using Hot Heavy Water

Matsubara, S.; Ishibashi, K.; Maung, G. Y. T.; Morota, Y.; Umemura, T.; Kato, Y.

Chimia 2018, 72, 853–858.

FeCl3 as an Ion-Pairing Lewis Acid Catalyst. Formation of Highly Lewis Acidic FeCl2+ and Thermodynamically Stable FeCl4– To Catalyze the Aza-Diels–Alder Reaction with High Turnover Frequency

Tomifuji, R.; Maeda, K.; Takahashi, T.; Kurahashi, T.; Matsubara, S.

Org. Lett. 2018, 20, 7474–7477.

Org. Lett. 2018, ASAP (Tomifuji).gif

Nickel-catalyzed Intermolecular Carboiodination of Alkynes with Aryl Iodides

Takahashi, T.; Kuroda, D.; Kuwano, T.; Yoshida, Y.; Kurahashi, T.; Matsubara, S.

Chem. Commun. 2018, 54, 12750–12753.

Chem. Commun. 2018, Advance Article (Tak

コンピュータ支援有機合成の現在

Matsubara, S.; Terayama, K.; Okuno, Y.

MEDCHEM NEWS 2018, 28 (4), 181–186.

trans‐Cyclooctenes as Halolactonization Catalysts

Einaru, S.; Shitamichi, K.; Nagano, T.; Matsumoto, A.; Asano, K.; Matsubara, S.

Angew. Chem., Int. Ed. 2018, 57, 13863–13867.

Highlighted in Synfacts 2018, 14, 1198.

Angew. Chem., Int. Ed. 2018, 57, 13863.p

Asymmetric Cycloetherification by Bifunctional Organocatalyst

Asano, K.; Matsubara, S.

Synthesis 2018, 50, 4243–4253.

Catalytic Approaches to Optically Active 1,5-Benzothiazepines

Asano, K.; Matsubara, S.

ACS Catal. 2018, 8, 6273–6282.

Chematicaは有機合成に新たな道を拓くのか?—AIと化学の未来像を探る

Matsubara, S.

Chemistry 2018, 73 (6), 12–18.

Ligand-controlled Behavior of Ag(I)–π Complex as σ-Lewis Acid

Maeda, K.; Takahashi, T.; Tomifuji, R.; Hirao, N.; Kurahashi, T.; Matsubara, S.

Chem. Lett. 2018, 47, 532–535.

Molecular Transformations Using Bis(iodozincio)methane­–The Role of Chelation in Main Group Organometallic Chemistry

Matsubara, S.

Bull. Chem. Soc. Jpn. 2018, 91, 82–86.

BCSJ Account/Review Collection.

2017

反応溶液の中身を見ようとした話 ~有機反応における「均一溶液」について~

Matsubara, S.

Chemistry & Chemical Industry 2017, 70, 1110–1112.

Organocatalytic Enantio- and Diastereoselective Cycloetherification via Dynamic Kinetic Resolution of Chiral Cyanohydrins

Yoneda, N.; Fujii, Y.; Matsumoto, A.; Asano, K.; Matsubara, S.

Nat. Commun. 2017, 8, 1397.

Press release on Kyoto University website.

Highlighted in Newspapers (Nikkei Shinbun & Kagaku Kogyo Nippo).

Highlighted in Synform 2018, 3, A33.

Highlighted in Organic Chemistry Highlights in Organic Chemistry Portal.

Asymmetric Net Cycloaddition for Access to Diverse Substituted 1,5-Benzothiazepines

Fukata, Y.; Yao, K.; Miyaji, R.; Asano, K.; Matsubara, S.

J. Org. Chem. 2017, 82, 12655–12668.

Highlighted in Abstracts in Organic Chemistry Portal.

Bifunctional Organocatalysts for the Asymmetric Synthesis of Axially Chiral Benzamides

Miyaji, R.; Wada, Y.; Matsumoto, A.; Asano, K.; Matsubara, S.

Beilstein J. Org. Chem. 2017, 13, 1518–1523.

Preparation of Organozinc Reagents via Catalyst Controlled Three-Component Coupling between Alkyne, Iodoarene, and Bis(iodozincio)methane

Shimada, Y.; Ikeda, Z.; Matsubara, S.

Org. Lett. 2017, 19, 33353337.

Highlighted in Synfacts 2017, 13, 973.

Induction of Axial Chirality in 8-Arylquinolines through Halogenation Reactions Using Bifunctional Organocatalysts

Miyaji, R.; Asano, K.; Matsubara, S.

Chem.—Eur. J. 2017, 23, 999610000.

Selected as the Inside Cover.

Chem.—Eur. J. 2017, in press_

“Naked” Lithium Cation: Strongly Activated Metal Cations Facilitated by Carborane Anions

Kitazawa, Y.; Takita, R.; Yoshida, K.; Muranaka, A.; Matsubara, S.; Uchiyama, M.

J. Org. Chem. 2017, 82, 1931–1935.

2016

Asymmetric Syntheses Utilizing Mild Activations by Organocatalysts

Asano, K.

J. Synth. Org. Chem., Jpn. 2016, 74, 1194–1205.

Asymmetric Cycloetherification via the Kinetic Resolution of Alcohols Using Chiral Phosphoric Acid Catalysts

Yoneda, N.; Matsumoto, A.; Asano, K.; Matsubara, S.

Chem. Lett. 2016, 45, 13001303.

2015

Asymmetric Synthesis of Spiroketals with Aminothiourea Catalysts

Yoneda, N.; Fukata, Y.; Asano, K.; Matsubara, S.

Angew. Chem., Int. Ed. 201554, 15497–15500.

Highlighted in Synfacts 2016, 12, 89.

Ruthenium-Porphyrin-Catalyzed [4 + 2] Cycloaddition of α,β-Unsaturated Imines

and Aldehydes

Maeda, K.; Terada, T.; Iwamoto, T.; Kurahashi, T.; Matsubara, S.

Org. Lett. 2015, 17, 5284–5287.

Chemo- and Regioselective Preparation of Zinc Enolate from Thiol Esters by Palladium Catalyzed Cross-coupling Reaction

Haraguchi, R.; Ikeda, Z.; Ooguri, A.; Matsubara, S.

Tetrahedron 201571, 8830–8837.

穏やかな触媒がもたらす精密有機合成

Asano, K.

Chemistry & Chemical Industry 2015, 68, 832–833.

Preparation of an Arenylmethylzinc Reagent with Functional Groups by Chemoselective Cross-Coupling Reaction of Bis(iodo­zincio)methane with Iodoarenes

Shimada, Y.; Haraguchi, R.; Matsubara, S.

Synlett 201526, 2395–2398.

Diastereoselective Reduction of β-(1,3-Dioxan-4-yl)ketones

Matsumoto, A.; Asano, K.; Matsubara, S.

Synlett 2015, 26, 1872–1874.

A Chiral Phosphoric Acid Catalyst for Asymmetric Construction of 1,3-Dioxanes

Matsumoto, A.; Asano, K.; Matsubara, S.

Chem. Commun. 2015, 51, 11693–11696.

A Triphenylamine with Two Phenoxy Radicals Having Unusual Bonding Patterns and a Closed-Shell Electronic State

Sakamaki, D.; Yano, S.; Kobashi, T.; Seki, S.; Kurahashi, T.; Matsubara, S.; Ito, A.; Tanaka, K.

Angew. Chem., Int. Ed. 2015, 54, 8267–8270.

Nickel-catalyzed Reactions Directed toward the Formation of Heterocycles

Kurahashi, T.; Matsubara, S.

Acc. Chem. Res. 2015, 48, 1703–1716.

Organozinc Reagents in a Flow-microreactor –From Methylenation to Asymmetric Autocatalysis–

Matsubara, S.

J. Synth. Org. Chem., Jpn. 2015, 73, 435–441.

Bifunctional Organocatalysts for the Enantioselective Synthesis of Axially Chiral Isoquinoline N-Oxides

Miyaji, R.; Asano, K.; Matsubara, S.

J. Am. Chem. Soc. 2015, 137, 6766–6769.

Facile Net Cycloaddition Approach to Optically Active 1,5‑Benzothiazepines
Fukata, Y.; Asano, K.; Matsubara, S.
J. Am. Chem. Soc. 2015, 137, 5320–5323.
Highlighted in Synfacts 2015, 11, 770.
Highlighted in J. Synth. Org. Chem., Jpn. 2015, 73, 1162.

Nickel-catalyzed Dual C–C σ Bond Activation to Construct Carbocyclic Skeletons

Nakai, K.; Kurahashi, T.; Matsubara, S.

Tetrahedron 2015, 71, 4512–4517.

Nickel-catalysed Synthesis of Tetrasubstituted Vinyl Sulfides from Thiocarbamates and Internal Alkynes

Inami, T.; Kurahashi, T.; Matsubara, S.

Chem. Commun. 2015, 51, 1285–1288.

Reasons Two Nonstrained C–C σ-Bonds Can Be Easily Cleaved in Decyanative [4 + 2] Cycloaddition Catalyzed by Nickel(0)/Lewis Acid Systems. Theoretical Insight

Guan, W.; Sakaki, S.; Kurahashi, T.; Matsubara, S.

ACS Catal. 20155, 1–10.

Preparation of Cycloheptane Ring by Nucleophilic Cyclopropanation of 1,2-Diketones with

Bis(iodozincio)methane

Haraguchi, R.; Takada, Y.; Matsubara, S.

Org. Biomol. Chem. 2015, 13, 241–247.

bottom of page